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The Journal of pediatrics · Feb 2010
Case ReportsFailure of resolution of portal fibrosis during omega-3 fatty acid lipid emulsion therapy in two patients with irreversible intestinal failure.
- Jason S Soden, Mark A Lovell, Kristin Brown, David A Partrick, and Ronald J Sokol.
- Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado Denver School of Medicine and The Children's Hospital, 13123 E 16th Ave, Box B290, Aurora, CO 80045, USA. soden.jason@tchden.org
- J. Pediatr. 2010 Feb 1;156(2):327-31.
AbstractParenteral omega-3 fatty acid lipid emulsions have been evaluated for their potential role in reversing intestinal failure-associated liver disease. We report our experience using Omegaven in 2 patients with irreversible intestinal failure and intestinal failure-associated liver disease. Despite biochemical and histologic improvement in cholestasis, both patients had persisting, significant portal fibrosis on liver biopsy.Copyright 2010 Mosby, Inc. All rights reserved.
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