• Robert Scragg, Sandy Slow, Alistair W Stewart, Lance C Jennings, Stephen T Chambers, Patricia C Priest, Christopher M Florkowski, Carlos A Camargo, and David R Murdoch.
• From the School of Population Health, University of Auckland, Auckland, New Zealand (R.S., A.W.S.); Department of Pathology, University of Otago, Christchurch, New Zealand (S.S., L.C.J., S.T.C., C.M.F., D.R.M.); Preventive and Social Medicine, University of Otago, Dunedin, New Zealand (P.C.P.); and Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (C.A.C.). r.scragg@auckland.ac.nz.
• Hypertension. 2014 Oct 1;64(4):725-30.

AbstractPrevious randomized controlled trials of vitamin D supplementation and blood pressure (BP) mainly have given vitamin D for short periods (<6 months) or at low doses (400 IU per day). This study aims to determine whether long-term high-dose vitamin D taken for 18 months lowers BP. Adults were recruited from a healthcare organization or university into a double-blind controlled trial and randomized to receive either vitamin D3 200 000 IU for 2 months followed by 100 000 IU monthly up to 18 months (n=161) or placebo (n=161). BP was measured at baseline, 5, and 18 months. Subjects had a mean (SD) age of 47.6 (9.7) years, 75% were women, and 94% were of European ancestry (white). Mean (SD) 25-hydroxyvitamin D3 changed from 73 (22) nmol/L at baseline to 124 (28) nmol/L at 18 months in the vitamin D group, and from 71 (22) nmol/L to 56 (22) nmol/L in the placebo group. Mean BP was similar for the vitamin D and placebo groups at baseline (123.4/76.3 versus 122.6/75.6 mm Hg; respectively). The mean change (95% confidence interval) in BP at 18 months minus baseline in the vitamin D group compared with placebo group was -0.6 (-2.8 to 1.6) mm Hg for systolic (P=0.61) and 0.5 (-1.1, 2.2) mm Hg for diastolic (P=0.53). Long-term vitamin D supplementation, which increased mean 25-hydroxyvitamin D3 concentration >100 nmol/L for 18 months, had no effect on systolic or diastolic BP in predominantly white, healthy adults without severe vitamin D deficiency. Beneficial effects on BP cannot be ruled out for other populations.© 2014 American Heart Association, Inc.

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