• J Clin Pharm Ther · Jun 1994

    Chemical stability and adsorption of succinylcholine chloride injections in disposable plastic syringes.

    • Y V Pramar, D Moniz, and D Hobbs.
    • College of Pharmacy, Xavier University of Louisiana, New Orleans 70125.
    • J Clin Pharm Ther. 1994 Jun 1;19(3):195-8.

    AbstractThe purpose of these investigations was to determine the stability and adsorption behaviour of succinylcholine chloride (SCC) when stored in plastic syringes. Drug degradation was monitored using the USP high-pressure liquid chromatography method. Solutions containing 20 mg/ml of SCC in 5% dextrose, and in normal saline, were studied at 5, 25 and 40 degrees C. The hydrolysis of SCC in i.v. fluids followed apparent zero-order kinetics. The manufacturer's recommended expiry period was found to be too conservative. If protected from light, storage at room temperature for up to 3 months can be safely recommended, without significant loss of chemical stability. However, microbiological quality assurance will need to be implemented and an appropriate shelf-life assigned on the basis of both microbiological and chemical stability data.

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