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J Invest Allerg Clin · Jan 2003
Case ReportsAnaphylaxis due to patent blue dye during lymphography, with negative skin prick test.
- Mariangiola Crivellaro, Gianenrico Senna, Annarita Dama, Patrizia Bonadonna, and Giovanni Passalacqua.
- Allergy Service, Verona General Hospital, Italy.
- J Invest Allerg Clin. 2003 Jan 1;13(1):71-2.
AbstractWe report here a case of anaphylaxis due to patent blue dye, which was administered to an adult female during a lymphographic intraoperative procedure. The patient was not atopic, and other possible causes of anaphylaxis (anesthetics, latex) had been carefully excluded through routine tests. The skin-prick test and patch test carried out with patent blue (PB) dye were negative, but the intradermal test with 100 microliters of the dye showed a remarkable positivity. There was no available commercial, specific IgE assay for PB dye, but the negativity of prick tests would exclude the involvement of an IgE-mediated mechanism. We want to highlight the possible danger derived from a dye that is considered inert, and that is now increasingly being used in surgical procedures.
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