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Clin. Vaccine Immunol. · Apr 2014
Intranasal administration of retinyl palmitate with a respiratory virus vaccine corrects impaired mucosal IgA response in the vitamin A-deficient host.
- Sherri L Surman, Bart G Jones, Rajeev Rudraraju, Robert E Sealy, and Julia L Hurwitz.
- Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
- Clin. Vaccine Immunol. 2014 Apr 1;21(4):598-601.
AbstractOur previous studies showed that intranasal vaccination of vitamin A-deficient (VAD) mice failed to induce normal levels of upper respiratory tract IgA, a first line of defense against respiratory virus infection. Here we demonstrate that the impaired responses in VAD animals are corrected by a single intranasal application of retinyl palmitate with the vaccine. Results encourage the clinical testing of intranasal vitamin A supplements to improve protection against respiratory viral disease in VAD populations.
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