• Clinical endocrinology · Oct 2001

    Comparative Study

    Association between lithium use and thyrotoxicosis caused by silent thyroiditis.

    • K K Miller and G H Daniels.
    • Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    • Clin. Endocrinol. (Oxf). 2001 Oct 1;55(4):501-8.

    ObjectiveTo determine the incidence of silent thyroiditis in lithium users and characterize lithium-associated thyrotoxicosis.DesignRetrospective record review.Patients400 consecutive patients (300 with Graves' disease and 100 with silent thyroiditis) who underwent radioiodine scanning of the thyroid.MeasurementsOdds of lithium exposure.ResultsThe odds of lithium exposure were increased 4.7-fold in patients with silent thyroiditis compared with those with Graves' disease (95% CI: 1.3, 17). Lithium-associated silent thyroiditis occurred with an incidence rate of approximately 1.3 cases per 1000 person-years, and lithium-associated thyrotoxicosis occurred with an incidence rate of approximately 2.7 cases per 1000 person-years, higher than the reported incidence rates of silent thyroiditis (< 0.03-0.28 cases per 1000 person-years) and of thyrotoxicosis (0.8-1.2 cases per 1000 person-years) in the general population.ConclusionThyrotoxicosis caused by silent thyroiditis might be associated with lithium use.

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