• Arch. Fr. Pediatr. · Dec 1985

    Review Historical Article

    [Pneumocystis carinii infections].

    • M Mojon.
    • Arch. Fr. Pediatr. 1985 Dec 1;42 Suppl 2:929-38.

    AbstractIn children, Pneumocystis carinii pneumonias occur mainly in cases of congenital or acquired immunodeficiencies. Definitive diagnosis rests on the visualization of the parasites, ideally by broncho-alveolar lavage. If the lavage is negative and the patient deteriorates, an open lung biopsy is the next best diagnostic method. Serological methods are unreliable. Treatment with trimethoprim-sulfamethoxazole (TMP) should be instituted as early as possible: a serum level of TMP between 5 and 10 micrograms/ml should be attained. If no improvement occurs after three days, pentamidine should be substituted. Systematic chemoprophylaxis should be given to all high-risk patients.

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