• Nihon Kyobu Shikkan Gakkai Zasshi · Feb 1996

    Case Reports

    [Two cases of primary Sjögren's syndrome with pulmonary involvement histopathological study of open-lung biopsy specimens].

    • T Hachiya, M Hayasaka, T Honda, M Takeda, T Hayano, K Fujimoto, K Kubo, M Sekiguchi, and M Hanyuuda.
    • First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto City, Japan.
    • Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Feb 1;34(2):204-9.

    AbstractWe report two cases of primary Sjögren's syndrome with pulmonary involvement, in which open lung biopsies were done. The patient in the first case was a 58-year-old woman and the patient in the second case was a 54-year-old woman. Both patients were admitted to our hospital because of dry coughing and exertional dyspnea. Chest X-ray films and CT scans showed interstitial shadows in both cases and multiple bullae in the first case. Pulmonary-function tests showed decreased diffusing capacity, and examination of bronchoalveolar lavage fluid revealed increased percentages of lymphocytes. Open-lung biopsy specimens showed thickening of the alveolar septa and interstitial mononuclear cell infiltration, composed predominantly of lymphocytes, with lymphoid follicles in both cases, and peribronchiolar mononuclear cell infiltration in the first case. Therefore, the histopathological diagnosis was cellular interstitial pneumonia with lymphoid follicles. Both patients were treated with oral corticosteroids. Symptoms were relieved and laboratory findings improved.

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