• Rev Esp Anestesiol Reanim · Jan 1996

    Randomized Controlled Trial Comparative Study Clinical Trial

    [Prolactinemia in children anesthetized with propofol].

    • M D del Campo-Martín, A Garrido-Chercoles, and L Pascual.
    • Servicio de Anestesiología y Reanimación, Hospital Nuestra Señora de Aránzazu, San Sebastián.
    • Rev Esp Anestesiol Reanim. 1996 Jan 1;43(1):7-11.

    ObjectivesTo assess the relation between plasma levels of prolactin and spontaneous movements in children anesthetized with propofol and to compare the prolactin endocrine response for 2 different techniques of anesthetic maintenance.Patients And MethodThis was a prospective study of 35 ASA I children between 4 and 11 years of age, with no history of epilepsy or febrile convulsions, who underwent herniorrhaphy or orchidopexy. The patients were not premedicated. Before induction they received 0.02 mg/kg atropine and 2.5 micrograms/kg i.v.; induction was with 4 mg/kg propofol and 0.5 mg/kg atracurium. For maintenance the sample was randomly divided into 2 groups. Group A (n = 18) received 10 mg/kg/h propofol and 40% O2/air. Group B (n = 17) received 1-0.7% isoflurane and 40% N2O/O2. We measured plasma levels of prolactin before induction (baseline prolactin) and after extubation (postoperative prolactin). We also assessed pain upon injection of propofol by observing and recording spontaneous movement.ResultsThe number of children who remained in the study was 24, with 14 in group A and 10 in group B. We observed a significant increase (p < 0.05) of postoperative prolactin in children with spontaneous movement (15.3 +/- 7.5 vs. 87.1 +/- 42.9 ng/ml) as well as in those with no movement (23.8 +/- 15.9 vs. 82.4 +/- 29.7 ng/ml). There were no significant differences between baseline prolactin (20.9 +/- 16.9 vs. 21.8 +/- 10.8 ng/ml) and postoperative levels (90 +/- 35.4 vs. 75 +/- 29 ng/ml) related to technique.ConclusionsIncrease in prolactin is unrelated to spontaneous movements, which are attributable to low induction dose. Differences in prolactin plasma levels are not related to anesthetic technique.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.