• Hepatology · Jul 2004

    Review

    Acetaminophen misconceptions.

    • Barry H Rumack.
    • University of Colorado School of Medicine, Greenwood Village, CO 80121, USA. barry@rumack.com
    • Hepatology. 2004 Jul 1;40(1):10-5.

    AbstractExamination of the pharmacokinetics of acetaminophen can decrease misconceptions involved in clinical evaluation. Enzyme patterns and acetaminophen levels must be related to time and known metabolic phenomena. A careful look at ethanol and nutrition, especially fasting demonstrates that therapeutic doses of acetaminophen do not place patients at a greater risk in either of these instances. An overdose of acetaminophen in a chronic alcohol abuser may result in more severe hepatotoxicity than in the nonalcoholic. CYP2E1 and glutathione must be evaluated simultaneously rather than in isolation. Glucuronidation capacity in humans is not a factor except in massively overdosed patients.

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