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- Morie A Gertz, Martha Q Lacy, Angela Dispenzieri, Suzanne R Hayman, Shaji K Kumar, Nelson Leung, and Dennis A Gastineau.
- Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. gertz.morie@mayo.edu
- Haematologica. 2007 Oct 1;92(10):1415-8.
AbstractOur objective was to determine whether the goal of high-dose therapy should be a partial hematologic response or a complete response. We analyzed 282 consecutive stem cell transplant patients. A partial hematologic response was achieved in 108 patients (38%), and 93 (33%) achieved a complete hematologic response. Survival rates of patients with complete, partial, or no response were significantly different (p<0.001), even after eliminating bias from early death. The degree of response was affected by the intensity of chemotherapy conditioning, septal thickness, and cardiac biomarkers. Hematologic response translates to longer survival.
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