• J. Am. Coll. Cardiol. · Sep 2011

    Comparative Study

    Geriatric congenital heart disease: burden of disease and predictors of mortality.

    • Jonathan Afilalo, Judith Therrien, Louise Pilote, Raluca Ionescu-Ittu, Giuseppe Martucci, and Ariane J Marelli.
    • Department of Medicine, McGill University, Montreal, Quebec, Canada.
    • J. Am. Coll. Cardiol. 2011 Sep 27;58(14):1509-15.

    ObjectivesThe study sought to measure the prevalence, disease burden, and determinants of mortality in geriatric adults with congenital heart disease (ACHD).BackgroundThe population of ACHD is increasing and aging. The geriatric ACHD population has yet to be characterized.MethodsPopulation-based cohort study using the Quebec Congenital Heart Disease Database of all patients with congenital heart disease coming into contact with the Quebec healthcare system between 1983 and 2005. Subjects with specific diagnoses of congenital heart disease and age 65 years at time of entry into the cohort were followed for up to 15 years. The primary outcome was all-cause mortality.ResultsThe geriatric ACHD cohort consisted of 3,239 patients. From 1990 to 2005, the prevalence of ACHD in older adults remained constant from 3.8 to 3.7 per 1,000 indexed to the general population (prevalence odds ratio: 0.98; 95% confidence interval [CI]: 0.93 to 1.03). The age-stratified population prevalence of ACHD was similar in older and younger adults. The most common types of congenital heart disease lesions in older adults were shunt lesions (60%), followed by valvular lesions (37%) and severe congenital heart lesions (3%). Type of ACHD and ACHD-related complications had a minor impact on mortality, which was predominantly driven by acquired comorbid conditions. The most powerful predictors of mortality in the Cox proportional hazards model were: dementia (hazard ratio [HR]: 3.24; 95% CI: 1.53 to 6.85), gastrointestinal bleed (HR: 2.79; 95% CI: 1.66 to 4.69), and chronic kidney disease (HR: 2.50; 95% CI: 1.72 to 3.65).ConclusionsThe prevalence of geriatric ACHD is substantial, although severe lesions remain uncommon. ACHD patients that live long enough acquire general medical comorbidities, which are the pre-eminent determinants of their mortality.Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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