• Mahyar Etminan, Bahi Takkouche, Francisco Caamaño Isorna, and Ali Samii.
• Division of Epidemiology, Royal Victoria and Vancouver Hospitals, Canada. Mahyar.etminan@mail.mcgill.ca
• BMJ. 2005 Jan 8;330(7482):63.

ObjectiveTo explore the association between migraine and risk of ischaemic stroke.DesignSystematic review and meta-analysis.Data SourcesObservational studies published between 1966 and June 2004 (identified through Medline and Embase) that examined the association between migraine and risk of ischaemic stroke.Results14 studies (11 case-control studies and 3 cohort studies) were identified. These studies suggest that the risk of stroke is increased in people with migraine (relative risk 2.16, 95% confidence interval 1.89 to 2.48). This increase in risk was consistent in people who had migraine with aura (relative risk 2.27, 1.61 to 3.19) and migraine without aura (relative risk 1.83, 1.06 to 3.15), as well as in those taking oral contraceptives (relative risk 8.72, 5.05 to 15.05).ConclusionsData from observational studies suggest that migraine may be a risk factor in developing stroke. More studies are needed to explore the mechanism of this potential association. In addition, the risk of migraine among users of oral contraceptives must be further investigated.

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