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Trends in microbiology · Sep 2013
Historical ArticleInsights into ancient leprosy and tuberculosis using metagenomics.
- Helen D Donoghue.
- Centres for Clinical Microbiology and The History of Medicine, University College London, London WC1E 6BT, UK. Electronic address: h.donoghue@ucl.ac.uk.
- Trends Microbiol. 2013 Sep 1;21(9):448-50.
AbstractLeprosy and tuberculosis were widespread in the past and remain significant diseases today. Comparison of ancient and modern genomes of Mycobacterium leprae and Mycobacterium tuberculosis gives insight into their evolution and a calibration of the timescale for observed changes. Recently, whole genome sequencing has revealed genotypes and mixed-strain infections.Copyright © 2013 Elsevier Ltd. All rights reserved.
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