• Ir J Med Sci · Sep 2010

    Non-steroidal anti-inflammatory drug prescriptions in hospital inpatients: are we assessing the risks?

    • J Kitchen and D Kane.
    • Department of Rheumatology, Adelaide and Meath Hospital incorporating the National Children's Hospital, Tallaght, Dublin 24, Ireland. kitchen.jo@gmail.com
    • Ir J Med Sci. 2010 Sep 1;179(3):357-60.

    AimTo determine non-steroidal anti-inflammatory drug (NSAID) prescribing practices in a tertiary referral hospital.MethodsA single time-point audit of drug kardexes and clinical notes of n = 388 patients on 2 July 2008 was carried out assessing demographics, gastrointestinal and coronary heart disease risk factors, renal function and co-prescribed medications.ResultsFifty-seven of 388 (14.7%) hospital patients were on NSAIDs. Forty-nine were prescribed NSAID after admission. Nineteen (32.2%) were on regular NSAID (11/19 on PPI) and 38 patients were on PRN NSAID (12/38 on PPI). Seventeen of 49 patients were on other medications associated with gastrointestinal bleeding (10/17 were on PPI). Nineteen patients (33.3%) were >60 years. Eight patients had three or four risk factors for gastrointestinal bleeding; six were on PPI. Thirteen patients had two risks; 7 were on PPI. Six of 19 patients with one risk factor were on PPI. 40.3% had stage 2/3 chronic kidney disease. 35.1% had ischaemic heart disease.ConclusionsNSAIDs and PPIs are often prescribed inappropriately.

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