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- Miguel Ángel López-Vázquez, Elisa López-Loeza, Naima Lajud Ávila, Blanca Erika Gutiérrez-Guzmán, J Jesús Hernández-Pérez, Yoana Estrada Reyes, and María Esther Olvera-Cortés.
- Laboratorio de Neuroplasticidad de los Procesos Cognitivos, Centro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, Mexico; Laboratorio de Biofísica, Instituto de Física y Matemáticas, Universidad Michoacana de San Nicolás de Hidalgo, Mexico.
- Eur. J. Pharmacol. 2014 Jul 5;734:105-13.
AbstractHippocampal theta activity, which is strongly modulated by the septal medial/Broca׳s diagonal band neurons, has been linked to information processing of the hippocampus. Serotonin from the medial raphe nuclei desynchronises hippocampal theta activity, whereas inactivation or a lesion of this nucleus induces continuous and persistent theta activity in the hippocampus. Hippocampal serotonin depletion produces an increased expression of high-frequency theta activity concurrent with the facilitation of place learning in the Morris maze. The medial septum-diagonal band of Broca complex (MS/DBB) has been proposed as a key structure in the serotonin modulation of theta activity. We addressed whether serotonin depletion of the MS/DBB induces changes in the characteristics of hippocampal theta activity and whether the depletion is associated with learning in a working memory spatial task in the radial arm maze. Sprague Dawley rats were depleted of 5HT with the infusion of 5,7-dihydroxytriptamine (5,7-DHT) in MS/DBB and were subsequently trained in the standard test (win-shift) in the radial arm, while the CA1 EEG activity was simultaneously recorded through telemetry. The MS/DBB serotonin depletion induced a low level of expression of low-frequency (4.5-6.5Hz) and a higher expression of high-frequency (6.5-9.5Hz) theta activity concomitant to a minor number of errors committed by rats on the working memory test. Thus, the depletion of serotonin in the MS/DBB caused a facilitator effect on working memory and a predominance of high-frequency theta activity.Copyright © 2014 Elsevier B.V. All rights reserved.
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