• A Hiraoka, T Masaoka, K Nagai, E Kakishita, S Oshiba, T Kageyama, K Okuda, N Tatsumi, H Uchino, and Y Matsuzawa.
• Center for Adult Diseases, Osaka.
• Gan To Kagaku Ryoho. 1993 Sep 1;20(12):1835-41.

AbstractThe efficacy and safety of oral granisetron against nausea and vomiting induced by chemotherapy for tumors in the hematopoietic organs were investigated. Depending on the day of anticancer drug administration, single administration or 2 to 6-day repeated administration of granisetron at 2 mg once daily was conducted. The clinical efficacy rate against nausea and vomiting was 91.6% on the first day of administration of anti-cancer drugs and 90% or over on and after the second day of administration. Compared with the status at the previous chemotherapy, a significant decrease in vomiting frequency was observed during the present trial. Adverse events which were suspected to be related to granisetron included 1 case of mild feeling of residual urine and another demonstrating very mild eosinophilia. From the above results, it was confirmed that granisetron was a safe and effective antiemetic against nausea and vomiting induced by anticancer drug administration.

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