• Semin. Pediatr. Surg. · Nov 2009

    Review

    Omega-3 lipids for intestinal failure associated liver disease.

    • Ivan R Diamond, Paul B Pencharz, and Paul W Wales.
    • Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children, Toronto, Canada.
    • Semin. Pediatr. Surg. 2009 Nov 1;18(4):239-45.

    AbstractIntestinal failure associated liver disease (IFALD) is one of the most common and devastating complications in infants with intestinal failure. Although multifactorial, its pathophysiology is clearly related to the administration of parenteral nutrition (PN), with a recent focus on the role of PN lipid emulsions. This paper will review the evidence for the use of omega-3 fatty acid PN lipid emulsions, which are proposed to have efficacy in the treatment of IFALD. Mechanisms explaining their effects will be considered as will future research directions.

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