• Surgery · Sep 1997

    Randomized Controlled Trial Clinical Trial

    Lamotrigine reduces total postoperative analgesic requirement: a randomized double-blind, placebo-controlled pilot study.

    • V Bonicalzi, S Canavero, F Cerutti, M Piazza, M Clemente, and A Chió.
    • Department of Neurosciences, Institute of Anesthesia, University of Turin, Torino, Italy.
    • Surgery. 1997 Sep 1;122(3):567-70.

    BackgroundPostoperative pain is undertreated. Lamotrigine, a new antiepileptic drug, has analgesic properties in its antisodium and antiglutamatergic effects. It may prevent postoperative pain. This pilot study assessed lamotrigine effects on postoperative pain.MethodsThis was a double-blind, randomized, placebo-controlled pilot study of 30 patients submitted to transurethral prostatectomy under spinal anesthesia and receiving 200 mg of lamotrigine 1 hour before spinal anesthesia.ResultsWe observed a statistically significant reduction in total analgesic assumption (p < 0.01) and in visual analog scale scores at 2 (p = 0.04), 4 (p < 0.01), and 6 (p = 0.04) hours after operation.ConclusionsLamotrigine may be an effective means of reducing postoperative pain.

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