• Oddbjørn Haugen, Marit Farstad, Venny Kvalheim, Stig Hammersborg, and Paul Husby.
• Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway.
• Perfusion. 2007 Jul 1;22(4):273-8.

IntroductionThis study investigated whether two levels of mean arterial pressure (MAP) during cardiopulmonary bypass did influence per-operative fluid shifts.MethodsSixteen pigs underwent 60 minutes of normothermic cardiopulmonary bypass (CPB) followed by 90 minutes of hypothermic CPB. Eight animals had a MAP of 60-80mmHg by norepinephrine (HP group). Another 8 animals had a MAP of 40-45 mmHg by phentolamine (LP group). Blood chemistry, plasma/interstitial colloid osmotic pressures, plasma volume, fluid balance, fluid extravasation rate and tissue water content were measured or calculated.ResultsThe plasma volume was significantly lower in the HP group compared with the LP group after 60 minutes of CPB. Net fluid balance was 0.18 (0.05) ml x kg(-1) x min(-1) in the HP group and 0.21 ml x kg(-1) x min(-1) in the LP group (P > 0.05) while fluid extravasation rate was 1.18 (0.5) and 1.13 (0.4) ml x kg(-1) x min(-1) in the HP group and the LP group during CPB (P > 0.05).ConclusionNet fluid balance and fluid extravasation rate were similar in the animals with elevated and with lowered MAP during CPB.

19 keywords...

hide…