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- Marie-Odile Guimond, Mathias Hallberg, Nicole Gallo-Payet, and Charlotta Wallinder.
- Service of Endocrinology and Department of Physiology and Biophysics, Faculty of Medicine, Université de Sherbrooke , Sherbrooke, J1H 5N4 Quebec, Canada.
- Acs Med Chem Lett. 2014 Oct 9;5(10):1129-32.
AbstractSaralasin and sarile, extensively studied over the past 40 years as angiotensin II (Ang II) receptor blockers, induce neurite outgrowth in a NG108-15 cell assay to a similar extent as the endogenous Ang II. In their undifferentiated state, these cells express mainly the AT2 receptor. The neurite outgrowth was inhibited by preincubation with the AT2 receptor selective antagonist PD 123,319, which suggests that the observed outgrowth was mediated by the AT2 receptor. Neither saralasin nor sarile reduced the neurite outgrowth induced by Ang II proving that the two octapeptides do not act as antagonists at the AT2 receptor and may be considered as AT2 receptor agonists.
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