• Neuroscience letters · Apr 2004

    Comparative Study

    Muscle-specific protein MDP77 specifically promotes motor nerve regeneration in rats.

    • Soichiro Itoh, Atsuko Uyeda, Yuko Hukuoka, Kazuhiro E Fujimori, Atsushi Matsuda, Shizuko Ichinose, Hisatoshi Kobayashi, Kenichi Shinomiya, Junzo Tanaka, and Takahisa Taguchi.
    • Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8519, Japan. itoso.gene@cmn.tmd.ac.jp
    • Neurosci. Lett. 2004 Apr 29;360(3):175-7.

    AbstractThis study has examined the effects of recombinant human MDP77 (rhMDP77) on sciatic motor nerve regeneration in vivo. We carried out bridge grafting (14 mm) into the sciatic nerve of Sprague-Dawley rats using silicone tubes containing a mixture of type-I collagen and 0, 5, 10, or 20 microg/ml of rhMDP77, or containing phosphate-buffered solution (N = 6 in each group). Electrophysiological and histological evaluations carried out 12 weeks after implantation suggest that rhMDP77 has a positive effect on terminal and collateral sprouting of regenerating nerves and thereby promotes motor nerve regeneration in a dose-dependent manner.

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