• Mohammad Ali Sahraian, Abdorreza Naser Moghadasi, Mahsa Owji, Hoda Naghshineh, and Alireza Minagar.
• MS Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran. msahari@sina.tums.ac.ir.
• J Med Case Rep. 2015 Jan 1;9:137.

IntroductionNeuromyelitis optica is a demyelinating disease of the central nervous system with various patterns of brain lesions. Corpus callosum may be involved in both multiple sclerosis and neuromyelitis optica. Previous case reports have demonstrated that callosal lesions in neuromyelitis optica are usually large and edematous and have a heterogeneous intensity showing a "marbled pattern" in the acute phase. Their size and intensity may reduce with time or disappear in the chronic stages.Case PresentationIn this report, we describe a case of a 25-year-old Caucasian man with neuromyelitis optica who presented clinically with optic neuritis and myelitis. His brain magnetic resonance imaging demonstrated linear enhancement of the corpus callosum. Brain images with contrast agent added also showed linear ependymal layer enhancement of the lateral ventricles, which has been reported in this disease previously.ConclusionsLinear enhancement of corpus callosum in magnetic resonance imaging with contrast agent could help in diagnosing neuromyelitis optica and differentiating it from other demyelinating disease, especially multiple sclerosis.

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