A rare case of hyperammonemia complication of high-protein

Jpen Parenter Enter · Jan 2013

Case Reports

A rare case of hyperammonemia complication of high-protein parenteral nutrition.

Hyperammonemia is a metabolic derangement that can be potentially fatal. Primary hyperammonemia due to urea cycle enzyme deficiency is usually discovered in neonates but rarely can present in adulthood. Late-onset manifestations of urea cycle disorders can go unnoticed, until they become life threatening. The authors report a 28-year-old man who developed hyperammonemia in the hospital following parenteral nutrition (PN), leading to cerebral edema, which was fatal despite resolution of the hyperammonemia with cessation of PN and the use of continuous renal replacement therapy.

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- Unnikrishnan Pillai, Roopkiranjot Kahlon, James Sondheimer, Pravit Cadnapaphorncai, and Zeenat Bhat.
- Wayne State University, Ste-908, John R Rd, Detroit, MI 48201, USA. unnikrishnanpk@yahoo.com
- Jpen Parenter Enter. 2013 Jan 1; 37 (1): 134-7.
AbstractHyperammonemia is a metabolic derangement that can be potentially fatal. Primary hyperammonemia due to urea cycle enzyme deficiency is usually discovered in neonates but rarely can present in adulthood. Late-onset manifestations of urea cycle disorders can go unnoticed, until they become life threatening. The authors report a 28-year-old man who developed hyperammonemia in the hospital following parenteral nutrition (PN), leading to cerebral edema, which was fatal despite resolution of the hyperammonemia with cessation of PN and the use of continuous renal replacement therapy.

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A rare case of hyperammonemia complication of high-protein parenteral nutrition.

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