• Stephane Legriel, Fabrice Bruneel, Odile Spreux-Varoquaux, Aurelie Birenbaum, Marie Laure Chadenat, François Mignon, Nathalie Abbosh, Matthieu Henry-Lagarrigue, Laure Revault D'Allonnes, Pierre Guezennec, Gilles Troche, and Jean Pierre Bedos.
• Service de Réanimation Polyvalente, Hôpital André Mignot, 78157, Le Chesnay, France. stlegriel@invivo.edu
• Neurocrit Care. 2008 Jan 1; 9 (2): 247-52.

IntroductionPosterior reversible encephalopathy syndrome (PRES) is known to occur in association with several substances. However, lysergic acid amide (LSA) is not among the previously reported causes of PRES.MethodsWe report on a patient with PRES presenting as convulsive status epilepticus associated with hypertensive encephalopathy after LSA ingestion. Magnetic resonance imaging was performed and catecholamine metabolites assayed.ResultsThe patient achieved a full recovery after aggressive antihypertensive therapy and intravenous anticonvulsivant therapy. The clinical history, blood and urinary catecholamine levels, and response to treatment strongly suggest that PRES was induced by LSA.ConclusionLSA, a hallucinogenic agent chiefly used for recreational purposes, should be added to the list of causes of PRES.

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