• Internal medicine · Jan 2013

    Case Reports

    Anaplastic large cell lymphoma mimicking fibrosing mediastinitis.

    • Masato Taki, Shinya Inada, Ryo Ariyasu, Yoshinobu Konishi, Natsumi Okamoto, Masanori Yoshida, Hiroaki Nagano, Kenji Hanaoka, Kazuhiko Nakagawa, Yasukiyo Nakamura, Chie Yoshimura, Toshiaki Wakayama, Yasuo Nishizaka, Tomoko Wakasa, Mitsuru Tsudo, and Ryoichi Amitani.
    • Department of Respiratory Medicine, Osaka Red Cross Hospital, Japan.
    • Intern. Med. 2013 Jan 1; 52 (23): 2645-51.

    AbstractFibrosing mediastinitis is rare. One type of this disease is idiopathic fibrosing mediastinitis. It is necessary to rule out malignancy in order to accurately diagnose fibrosing mediastinitis. We herein report a case of anaplastic large cell lymphoma diagnosed three months after a preliminary diagnosis of fibrosing mediastinitis. Glucocorticoid therapy was not successful in controlling disease progression. Immediately after initiating chemotherapy for lymphoma, the patient's symptoms improved dramatically and the mediastinal lesion decreased in size. Although few similar cases have been reported, hidden malignancy may present as fibrosing mediastinitis. Therefore, physicians should consider the probability of malignancy in patients with fibrosing mediastinitis because treatments may vary accordingly.

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