• Yiping Wang, Fei Xiao, Jiajia Li, Hong Pu, and Xiaobo Huang.
• Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China.
• Zhonghua Yi Xue Za Zhi. 2015 May 19; 95 (19): 1448-52.

ObjectiveTo investigate the ideal persistence time of prone position ventilation in patients with severe acute respiratory distress syndrome (ARDS).MethodsCollect 78 cases of severe ARDS admitted to the ICU unit of Sichuan Provincial People's Hospital from October 2012 to June 2014, all the ARDS patients needed to receive 8 h/day prone position continuous 5 day. For each of the prone position ventilation, ultrasound patterns were recorded and the aeration scores were calculated at the beginning of the prone position (T0) and 2 h (T1), 4 h (T2), 6 h (T3), 8 h (T4) later. The correlation of the aeration score variation (ASV) and the arterial blood gas indexes (pH, PaO(2), PaCO(2), PaO(2)/FiO(2)) were recorded also. The adverse reactions, ventilator situation and oxygen fraction after 7 days, 28-day mortality were monitored.ResultsThe aeration score of the lung at T1, T2, T3, T4 was significantly reduced than T0 all, the ventilation situation of mainly areas was improved after 2 h PPV (P < 0.05), 4 h later it was not distinguished (P > 0.05); the value of PaO(2), PaO(2)/FiO(2) was greater at T1, T2, T3, T4 than T0 (P < 0.05), the value of the oxygen fraction was significant increased at T2 than T1 (t = 2.840, P < 0.05); the number of patients with oxygen fractions > 300 mmHg after 5 days PPV was 65 (83.3%); there were 30 (38.5%) patients free of mechanical ventilation after 7 days; the 28-day mortality was 7 (8.97%).ConclusionIn patients with severe ARDS, applicating 2-4 hours validity of prone position ventilation significantly improves the pulmonary ventilation, more than 4 h PPV do not better for patients probably.

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