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Pediatr Crit Care Me · Jan 2010
Case ReportsWithdrawal from multiple sedative agent therapy in an infant: is dexmedetomidine the cause or the cure?
- Cindy Darnell, Jeff Steiner, Peter Szmuk, and Paul Sheeran.
- University of Texas Southwestern Medical Center, Children's Medical Center, Dallas, TX, USA. cindy.darnell@childrens.com
- Pediatr Crit Care Me. 2010 Jan 1; 11 (1): e1-3.
ObjectiveTo report withdrawal symptoms experienced by an infant following the prolonged use of dexmedetomidine.DesignCase report.SettingPediatric intensive care unit at a freestanding tertiary care children's hospital.PatientsOne pediatric patient with respiratory failure following pertussis infection that required prolonged intubation and sedation. The patient required dexmedetomidine to maintain optimal sedation before ventilator weaning. Subsequent to receiving dexmedetomidine the patient developed withdrawal symptoms.ConclusionIn patients who fail to achieve adequate sedation with the use of traditional medications, dexmedetomidine is an adequate alternative. However, abrupt discontinuation of dexmedetomidine may result in withdrawal symptoms that may be avoided with a dexmedetomidine taper.
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