• Pedro E Bermejo, Cristina V Torres, and Rafael G Sola.
• Hospital Universitario Puerta de Hierro-Majadahonda, 28035 Majadahonda, Espana.
• Rev Neurol. 2015 Jun 1; 60 (11): 509-16.

IntroductionOccipital nerve stimulation (ONS) is an emerging and promising preventive treatment for refractory chronic migraine.AimTo evaluate the mechanisms of actions, clinical studies, implantation techniques and inclusion criteria of the ONS as a preventive treatment for migraine.DevelopmentThis work includes a non-systematic review of the literature on the above-mentioned aspects of ONS as a treatment for refractory chronic migraine. This disease affects approximately 2% of the population and results in a significant impairment in quality of life, economic burden and interference with labor and social activities. ONS is an emerging and promising therapy for the treatment of chronic migraine with greater than 50% pain reduction in most of open-label studies and published clinical trials. Although the mechanisms of action remain unknown, there seem to be a neuromodulation of the transmitted nociceptive trigeminal information in the trigeminal caudal nucleus, what could be explained by means of the Melzack and Wall pain gate theory. ONS is a safe and well tolerated treatment, and its most frequent side effects are usually local such as electrodes displacement or infections of the surgical incision. These complications do not usually require the electrodes withdrawal.ConclusionsONS is an effective, well tolerated and safe treatment for the prevention of chronic migraine and could emerge as a useful option for those patients with medically refractory chronic migraine.

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