• J Am Acad Child Adolesc Psychiatry · May 1993

    Treatment of aggressive children with clonidine: results of an open pilot study.

    • J P Kemph, C L DeVane, G M Levin, R Jarecke, and R L Miller.
    • Department of Psychiatry, University of Florida, Gainesville 32610-0486.
    • J Am Acad Child Adolesc Psychiatry. 1993 May 1; 32 (3): 577-81.

    AbstractSeventeen aggressive children (14 boys and 3 girls) aged 5 to 15 years, who were characterized by cruel behavior to others and destruction of property, entered an open pilot study using clonidine to evaluate its efficacy and safety and drug-induced changes in plasma gamma aminobutyric acid (GABA). Aggression decreased in 15 children with minimal side effects. In five cases, GABA increased from 105.4 +/- 15.2 ng/mL at baseline to 125.2 +/- 10.8 ng/mL at follow-up (p < 0.01). A sixth patient was noncompliant. These findings suggest that GABA may be correlated with childhood aggressiveness and may be a useful marker of drug compliance. Pharmacotherapy with clonidine should be further assessed for the control of aggression.

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