• Benoît Misset, Bernard De Jonghe, Sylvie Bastuji-Garin, Olivier Gattolliat, Ezzeddine Boughrara, Djillali Annane, Pierre Hausfater, Maïté Garrouste-Orgeas, and Jean Carlet.
• Intensive Care Unit, Fondation Hôpital Saint-Joseph, Paris, France.
• Crit. Care Med. 2006 Apr 1; 34 (4): 1087-92.

ObjectiveHeatstroke requires active body cooling and organ failure supportive care. Although heat waves are expected to recur over the next decades, little is known about the risk factors for mortality in heatstroke patients. We examined the prognosis and risk factors for hospital mortality in patients with heatstroke admitted to an intensive care unit (ICU) during the heat wave in France in August 2003.DesignA questionnaire was sent to the physicians leading an ICU in France to identify the patients admitted with heatstroke during August 2003. Data included demographics, factors predisposing to heatstroke, severity during the first day in the ICU, air conditioning in the ICU, and hospital mortality. Risk factors for mortality were determined in multivariate Cox proportional hazards analysis.InterventionsNone.Measurements And Main ResultsData were obtained for 345 patients. Hospital mortality was 62.6%. Occurrence of heatstroke at home or in a healthcare facility rather than in a public location, high Simplified Acute Physiology Score II, high body temperature, prolonged prothrombin time, use of vasoactive drugs within the first day in the ICU, and patient management in an ICU without air conditioning were independently associated with an increased risk of death.ConclusionsMortality of patients admitted to the ICU with heatstroke is high. Predictors of mortality are available within the first 24 hrs after admission. Furthermore, in this study, air conditioning in the ICU was associated with improved outcome.

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