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Clin Neuropharmacol · Mar 2008
Case ReportsCutaneous drug eruptions by current antiepileptics: case reports and alternative treatment options.
- Sevki Sahin, Asuman Comert, Ozlem Akin, Sunay Ayalp, and Sibel Karsidag.
- Department of Neurology, Faculty of Medicine, Maltepe University, Istanbul, Turkey. drsahin@gmail.com
- Clin Neuropharmacol. 2008 Mar 1; 31 (2): 93-6.
AbstractSerious cutaneous drug eruptions due to antiepileptics have been defined for many drugs like carbamazepine, diphenylhydantoin, phenytoin and valproate. In recent years, adverse cutaneous reactions due to the current antiepileptic drugs have also been reported. In this paper, two cases are presented: a 48-year-old female receiving gabapentin for postherpetic neuralgia who developed leukocytoclastic vasculitis after 8 weeks and a 23-year-old male receiving lamotrigine for epileptic seizures who developed toxic epidermal necrolysis (TEN) in 15 days. Alternative therapy approaches with practical suggestions are also discussed.
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