• Neurology · Mar 2007

    Clinical Trial

    Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis.

    • D Centonze, G Koch, V Versace, F Mori, S Rossi, L Brusa, K Grossi, F Torelli, C Prosperetti, A Cervellino, G A Marfia, P Stanzione, M G Marciani, L Boffa, and G Bernardi.
    • Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata, Rome, Italy. centonze@uniroma2.it
    • Neurology. 2007 Mar 27; 68 (13): 1045-50.

    ObjectiveTo investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity.MethodsWe used high-frequency (5 Hz) and low-frequency (1 Hz) rTMS protocols in 19 remitting patients with relapsing-remitting multiple sclerosis and lower limb spasticity.ResultsA single session of 1 Hz rTMS over the leg primary motor cortex increased H/M amplitude ratio of the soleus H reflex, a reliable neurophysiologic measure of stretch reflex. Five hertz rTMS decreased H/M amplitude ratio of the soleus H reflex and increased corticospinal excitability. Single sessions did not induce any effect on spasticity. A significant improvement of lower limb spasticity was observed when rTMS applications were repeated during a 2-week period. Clinical improvement was long-lasting (at least 7 days after the end of treatment) when the patients underwent 5 Hz rTMS treatment during a 2-week protocol. No effect was obtained after a 2-week sham stimulation.ConclusionsRepetitive transcranial magnetic stimulation may improve spasticity in multiple sclerosis.

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