• B K Wagner, K E Zavotsky, J B Sweeney, B A Palmeri, and J S Hammond.
• Department of Pharmacy Practice, College of Pharmacy, Rutgers University, Piscataway, New Jersey, USA.
• Pharmacotherapy. 1998 Mar 1; 18 (2): 358-63.

Study ObjectiveTo investigate patient recall of therapeutic paralysis (TP) in a surgical critical care unit.DesignProspectively applied structured interview of patients undergoing TP over 18 months.SettingSurgical critical care unit with 27 beds at a tertiary care university teaching hospital.PatientsForty patients admitted for postoperative care after coronary artery bypass graft surgery, trauma, or gastrointestinal surgery.InterventionsPatients received TP and concurrent sedation with benzodiazepines, propofol, and narcotics.Measurements And Main ResultsAfter the end of TP patients were asked to recall the experience, and their responses were ranked on a four-point ordinal scale. Four of 11 patients recalled mostly negative events and experiences with TP, such as sleeplessness, discomfort, pain, anxiety, and inconsistent caregiver communication. All patients with recall experienced fear, anxiety, and sleeplessness. Single-drug therapy with propofol and inadequate benzodiazepine dosing were linked to patient recall.ConclusionsPatient recollection from TP may be more common than appreciated and is generally unpleasant. Adequate dosing with benzodiazepines and narcotics is warranted to prevent recall and discomfort.

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