• Curr. Opin. Neurobiol. · Feb 2015

    Review

    Antidepressant actions of ketamine: from molecular mechanisms to clinical practice.

    • Lisa M Monteggia and Carlos Zarate.
    • Department of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9111, USA. Electronic address: lisa.monteggia@utsouthwestern.edu.
    • Curr. Opin. Neurobiol. 2015 Feb 1; 30: 139-43.

    AbstractIn the past decade the emergence of glutamate N-methyl-d-aspartate (NMDA) receptor blockers such as ketamine as fast-acting antidepressants fostered a major conceptual advance by demonstrating the possibility of a rapid antidepressant response. This discovery brings unique mechanistic insight into antidepressant action, as there is a substantial amount of basic knowledge on glutamatergic neurotransmission and how blockade of NMDA receptors may elicit plasticity. The combination of this basic knowledge base and the growing clinical findings will facilitate the development of novel fast acting antidepressants.Copyright © 2014 Elsevier Ltd. All rights reserved.

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