• Am J Infect Control · Dec 2010

    Comparative Study

    Povidone-iodine against sodium hypochlorite as skin antiseptics in volunteers.

    • Jose A Alvarez, Juan H Macias, Alejandro E Macias, Edmundo Rodríguez, Juan M Muñoz, Juan L Mosqueda, and Samuel Ponce de Leon.
    • University of Guanajuato, 20 de Enero 929, Leon Guanajuato, Mexico. micros_iesus@yahoo.com
    • Am J Infect Control. 2010 Dec 1; 38 (10): 822-5.

    BackgroundThis study was conducted to compare the antiseptic efficacy of sodium hypochlorite of electrochemical production with that of povidone-iodine in human voluntaries.MethodsThree areas of 25 cm(2) each were selected from the forearms; 1 was designated as control to determine the baseline bacterial count; and 2 more were selected to swab 10% povidone-iodine or 10% sodium hypochlorite. Every volunteer was studied on 3 separated occasions. Quantitative skin cultures were performed on agar plates containing a neutralizer.ResultsForty-eight healthy subjects were enrolled for a total of 144 determinations for every antiseptic and control. The bacterial counts from the control areas showed a median of 1500 colony-forming units (CFU)/cm(2). For the areas treated with sodium hypochlorite, the median was 192 CFU/cm(2). For the areas treated with povidone-iodine, the median was 231 CFU/cm(2). When the colony counts for the areas treated with antiseptics were compared with those of the controls, the difference was significant (Kruskal-Wallis test (H) = 55.7, P < .001). The difference in counts between the areas treated with antiseptics was not significant (difference in z values <1960).ConclusionThe present study did not find differences in antiseptic action between 10% povidone iodine and 10% sodium hypochlorite.Copyright © 2010 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

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