• William J Mack, Judy Huang, Christopher Winfree, Grace Kim, Marcelo Oppermann, John Dobak, Becky Inderbitzen, Steve Yon, Sulli Popilskis, Juan Lasheras, Robert R Sciacca, David J Pinsky, and E Sander Connolly.
• Department of Neurosurgery, Columbia University, New York, NY, USA.
• Stroke. 2003 Aug 1; 34 (8): 1994-9.

Background And PurposeHypothermia has been shown to be neuroprotective in a variety of clinical settings. Unfortunately, poor delivery techniques and insufficient data in appropriate preclinical models have hampered its development in human stroke. To address these limitations, we have devised a 10F intravascular catheter capable of rapid systemic cooling of nonhuman primates.MethodsPlaced in the inferior vena cava via a transfemoral approach, the catheter was used to induce mild systemic hypothermia 3 hours after the onset of hemispheric stroke in baboons.ResultsCooling was achieved at a rate of 6.3+/-0.8 degrees C/h. Target brain temperatures (32.2+/-0.2 degrees C) were reached at the same time (47.7+/-6.32 minutes) as target esophageal temperatures (32.0+/-0.0 degrees C). Hypothermia was maintained for 6 hours in all animals. Animals did not experience the infections, coagulopathy, or cerebral edema commonly seen with surface cooling methods in human stroke.ConclusionsThese data suggest that a brief episode of mild core hypothermia instituted at a clinically relevant time point can be achieved in primate stroke and that our intravascular cooling technique provides safe, rapid, and reproducible hypothermia.

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