• F Mearelli, D Orso, N Fiotti, N Altamura, A Breglia, M De Nardo, I Paoli, M Zanetti, C Casarsa, and G Biolo.
• Unit of Clinica Medica Generale e Terapia Medica, Surgical Health Sciences, Department of Medical, University of Trieste, Strada di Fiume Cattinara, Trieste, 447 34149, Italy, filippome@libero.it.
• Infection. 2015 Feb 1; 43 (1): 1-11.

IntroductionA growing body of evidence points out that a large amount of patients with sepsis are admitted and treated in medical ward (MW). With most of the sepsis studies conducted in intensive care unit (ICU), these patients, older and with more comorbidities have received poor attention. Provided the differences between the two groups of patients, results of diagnostic and therapeutic trials from ICU should not be routinely transferred to MW, where sepsis seems to be at least as common as in ICU.MethodsWe analyzed clinical trials on novel tools for an early diagnosis of sepsis published in the last two year adopting strict research criteria. Moreover we conducted a target review of the literature on non-invasive monitoring of severe sepsis and septic shock.Results And ConclusionsThe combination of innovative and non-invasive tools for sepsis rule in/out, as quick alternatives to blood cultures (gold standard) with bedside integrated ultrasonography could impact triage, diagnosis and prognosis of septic patients managed in MW, preventing ICU admissions, poor outcomes and costly complications, especially in elderly that are usually highly vulnerable to invasive procedures.

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