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Expert Opin. Ther. Targets · Jan 2009
ReviewTRP channels as emerging targets for pain therapeutics.
- Lisa M Broad, Adrian J Mogg, Ruth E Beattie, Ann-Marie Ogden, Maria-Jesus Blanco, and David Bleakman.
- Eli Lilly and Company, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, UK. broad_lisa@lilly.com
- Expert Opin. Ther. Targets. 2009 Jan 1; 13 (1): 69-81.
BackgroundThe transient receptor potential (TRP) superfamily of ion channels are a large and diverse group that have received increased attention in recent years. The sub-family of thermo-TRPs which are regulated by temperature, among other physical and chemical stimuli, are of particular interest for the development of potential pain therapeutics.Objective/MethodsWe review the advances in the field in recent years, focusing on a rationale for pain therapy and potential challenges associated with these targets.Results/ConclusionsVanilloid-type TRP 1 (TRPV1) is the most well studied and advanced member of the family, with selective agonists and antagonists already in clinical use or development, respectively. Among other thermo-TRPs (including TRPV2 - 4, Ankyrin type TRP 1 (TRPA1) and melastatin type TRP 8 (TRPM8)), TRPA1 and TRPM8 are emerging as promising novel pain targets.
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