• H C Pape, F Hildebrand, and C Krettek.
• Unfallchirurgische Klinik, Medizinische Hochschule Hannover. pape.hans-christoph@mh-hannover.de
• Unfallchirurg. 2004 Oct 1; 107 (10): 927-36.

ObjectiveConcepts for optimal surgical treatment of the patient with blunt multiple injuries are being evaluated on the basis of the current literature.MethodsClinical trials were systematically collected (Medline, Cochrane and hand searches) and classified into evidence levels (1 to 5 according to the Oxford system).ResultsThe posttraumatic clinical course is divided into four different periods: acute-, primary-, secondary- und tertiary period. The first and second period are important for life saving surgery and the stabilization of major fractures. After the cardiorespiratory systems have been stabilized, the following priorities have been formulated: head, face, spine, abdomen, extremities. To restrict the degree of operative burden on the patient it appears to be necessary to limit the duration of initial surgery to less than 6 hours. In patients at high risk to develop posttraumatic complications-"borderline patients"-it appears safer to perform only temporary fixation of major fractures.ConclusionsThree different factors determine the clinical course after polytrauma: Trauma represents the first hit, followed by the therapy-induced burden (second hit). In addition, the third hit is represented by the individual response. An evaluation of the clinical status by immunologic monitoring can be performed in order to assess the patient's status.

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