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- Bulent Un, Dilek Ceyhan, and Birgul Yelken.
- Department of Anesthesiology and Reanimation, School of Medicine, Osmangazi University, Eskisehir, Turkey.
- J Res Med Sci. 2011 Nov 1; 16 (11): 1490-4.
BackgroundEtomidate frequently leads to myoclonic jerks during anesthetic induction. This study aimed to detect if pretreatment with magnesium decreases myoclonus incidence.MethodsA hundred ASA (the American Society of Anesthesiologists) I-II patients were included and randomized into 2 groups. Three minutes before etomidate induction of anesthesia (by 0.3 mg/kg intravenous etomidate), Group M received 2.48 mmol (60 mg) intravenous magnesium sulphate and Group P received equal volume of intravenous saline. Myoclonus was evaluated as "present/absent".ResultsThe rate of myoclonus was significantly lower in Group M than in Group P (p < 0.01). Hemodynamic parameters revealed no significant difference between the two groups.ConclusionsLow dose magnesium pretreatment before etomidate induction of anesthesia significantly reduces unwanted myoclonic jerks and also protects the hemodynamic stability.
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