• Curr Vasc Pharmacol · Jul 2005

    Review

    Role of nitrosative stress and poly(ADP-ribose) polymerase activation in myocardial reperfusion injury.

    • Gábor Szabó and Susanne Bährle.
    • Department of Cardiac Surgery, University of Heidelberg, Germany. dzsi@hotmail.com
    • Curr Vasc Pharmacol. 2005 Jul 1; 3 (3): 215-20.

    AbstractIschemia and reperfusion injury leads to a complex pathophysiological process, which in turn results in the generation of free radicals. Peroxynitrite, a highly reactive species causes DNA single strand breaks, which activates the nuclear enzyme, poly (ADP-ribose) polymerase (PARP). The activation of PARP leads to an energy consuming inefficient repair cycle with subsequent depletion of NAD(+) and ATP pools and necrotic cell death. The present review overviews the pathophysiological role of the peroxynitrite-PARP pathway in cardiac ischemia/reperfusion injury with special reference to the therapeutic potential of PARP inhibitors in the treatment of this disease.

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