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Eur. J. Clin. Microbiol. Infect. Dis. · Jun 1988
In vivo significance of the inoculum effect of antibiotics on Escherichia coli.
- F Soriano, M Santamaría, C Ponte, C Castilla, and R Fernández-Roblas.
- Department of Clinical Microbiology, Fundación Jiménez Diaz, Madrid, Spain.
- Eur. J. Clin. Microbiol. Infect. Dis. 1988 Jun 1; 7 (3): 410-2.
AbstractThe minimum dosage of antibiotics which reduced mortality in rats intraperitoneally inoculated with an Escherichia coli isolate was determined. Low mortality rates (0-10%) were obtained when antibiotics with minimal or no inoculum effect (cefoxitin, cefmetazole and gentamicin) were administered to yield serum levels 3 to 20 times the MIC, while antibiotics with a pronounced inoculum effect (cefotaxime and aztreonam) had to be administered to yield serum levels 200 to 1,000 times the MIC determined with a standard (low) inoculum. Thus, it seems that the inoculum effect observed in vitro with some antibiotics for Escherichia coli may have clinical significance.
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