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- J C Docherty, B A Schacter, G D Firneisz, and S B Brown.
- J. Biol. Chem. 1984 Nov 10; 259 (21): 13066-9.
AbstractThe formation of bile pigment from heme by a reconstituted heme oxygenase system containing purified bovine spleen heme oxygenase, NADPH-cytochrome P-450 reductase, and biliverdin reductase was studied under an atmosphere containing 18,18O2. The product, bilirubin, was isolated and subjected to mass spectrometry, which revealed incorporation of 18O consistent with a two-molecule mechanism, whereby the product bile pigment contains oxygen atoms derived from two different oxygen molecules.
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