• Jeremy T Affolter, W Charles Huskins, Michele Moss, Evelyn M Kuhn, Rainer Gedeit, and Thomas B Rice.
• 1Pediatrics, Critical Care Section, Medical College of Wisconsin, Milwaukee, WI. 2Pediatrics, Infectious Disease Section, Mayo Medical Center, Rochester, MN. 3Pediatrics, Critical Care Section, University of Arkansas Medical School, Little Rock, AR. 4Children's Hospital of Wisconsin, Milwaukee, WI.
• Pediatr Crit Care Me. 2016 Jul 1; 17 (7): 591-7.

ObjectiveCentral-line-associated bloodstream infections comprise 25% of device-associated infections. Compared with other units, PICUs demonstrate a higher central-line-associated bloodstream infections prevalence. Prior studies have not investigated the association of central-line-associated bloodstream infections prevalence, central-line utilization, or maintenance bundle compliance between specific types of PICUs.DesignThis study analyzed monthly aggregate data regarding central-line-associated bloodstream infections prevalence, central-line utilization, and maintenance bundle compliance between three types of PICUs: 1) PICUs that do not care for cardiac patients (PICU); 2) PICUs that provide care for cardiac and noncardiac patients (C/PICU); or 3) designated cardiac ICUs (CICU).SettingThe included units submitted data as part of The Children's Hospital Association PICU central-line-associated bloodstream infections collaborative from January 1, 2011, to December 31, 2013.PatientsPatients admitted to PICUs in collaborative institutions.InterventionsNone.Measurements And Main ResultsThe overall central-line-associated bloodstream infections prevalence was low (1.37 central-line-associated bloodstream infections events/1,000 central-line days) and decreased over the time of the study. Central-line-associated bloodstream infections prevalence was not related to the type of PICU although C/PICU tended to have a higher central-line-associated bloodstream infections prevalence (p = 0.055). CICU demonstrated a significantly higher central-line utilization ratio (p < 0.001). However, when examined on a unit level, central-line utilization was not related to the central-line-associated bloodstream infections prevalence. The central-line maintenance bundle compliance rate was not associated with central line-associated bloodstream infections prevalence in this unit-level investigation. Neither utilization rate nor compliance rate changed significantly over time in any of the types of units.ConclusionsAlthough this unit-level analysis did not demonstrate an association between central-line-associated bloodstream infections prevalence and central-line utilization and maintenance bundle compliance, optimization of both should continue, further decreasing central-line-associated bloodstream infections prevalence. In addition, investigation of patient-specific factors may aid in further central-line-associated bloodstream infections eradication.

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