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Pharmacol. Biochem. Behav. · Mar 1998
Comparative StudyDifferential involvement of opioid receptors in intrathecal butorphanol-induced analgesia: compared to morphine.
- W Wongchanapai, B K Tsang, Z He, and I K Ho.
- Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216, USA.
- Pharmacol. Biochem. Behav. 1998 Mar 1; 59 (3): 723-7.
AbstractThe present experiments were performed to investigate the differential involvement of the opioid receptor subtypes in the antinociception of intrathecal (IT) butorphanol compared to IT morphine. A single dose (26 nmol) of IT nor-binaltorphimine (nor-BNI), beta-funaltrexamine (beta-FNA), and naltrindole (NTI) demonstrated a significant attenuation in the overall antinociception of IT butorphanol (52 nmol) or IT morphine (26 nmol). However, IT butorphanol elicits thermal antinociceptive effect through kappa > delta > or = mu, whereas morphine acts on mu >delta > kappa. These results indicate that the antinociceptive effect of both IT butorphanol and IT morphine are mediated through mu, delta, and kappa opioid receptors in different relative orders.
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