• Ming-Han Tsai, Shih-Hsiang Chen, Chih-Yi Hsu, Dah-Chin Yan, Meng-Hsiu Yen, Cheng-Hsun Chiu, Yhu-Chering Huang, and Tzou-Yien Lin.
• Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan.
• J. Trop. Pediatr. 2008 Dec 1; 54 (6): 390-4.

AbstractPneumococcal meningitis causes high morbidity or mortality in childhood despite the progress in medicine. Children with pneumococcal meningitis were identified and retrospectively reviewed. Forty-nine children were eligible, with mortality in 24.5% of all and neurological sequelae in 40.5% of survivors. In the analysis of clinical profiles, ventilator support (p = 0.001), septic shock (p < 0.001), multiple organ failure (p < 0.001) and lower cerebrospinal fluid (CSF) leukocyte count (p = 0.001) were more frequently found in non-survivors. Besides, CSF protein (p = 0.006) was higher in survivors with neurological sequelae. Initial dexamethasone usage and disease severity did not affect the occurrence of neurological sequelae. Multivariate logistic regression analysis revealed that CSF leukocyte count or=330 g l(-1) (p = 0.022) were significantly risk factors associated with poor outcomes, and physicians should be cautious if such conditions occur.

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