• Orthop. Clin. North Am. · Jan 2016

    Review

    Application of Tranexamic Acid in Trauma and Orthopedic Surgery.

    • John D Jennings, Mark K Solarz, and Christopher Haydel.
    • Department of Orthopaedics and Sports Medicine, Temple University Hospital, 3401 North Broad Street, Zone B 5th Floor, Philadelphia, PA 19140, USA. Electronic address: john.jennings2@tuhs.temple.edu.
    • Orthop. Clin. North Am. 2016 Jan 1; 47 (1): 137-43.

    AbstractTranexamic acid has gained recent interest in orthopedics and trauma surgery because of its demonstrated benefit in several clinical trials. It is inexpensive and effective at reducing blood loss and blood transfusion requirements without a significant increase in morbidity or mortality. The optimal timing, dosing, and route of administration in orthopedics are yet to be elucidated. Significant investigation of tranexamic acid use in joint replacement and spine surgery has promoted its incorporation into the everyday practice of many of these surgeons. The paucity of studies regarding its use in orthopedic trauma has limited its integration into a field that may stand to benefit most from the drug.Copyright © 2016 Elsevier Inc. All rights reserved.

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