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Journal of hepatology · Apr 2008
Case ReportsSignificant improvement of portopulmonary hypertension after 1-week terlipressin treatment.
- Georgios Kalambokis, Panagiotis Korantzopoulos, Spyros A Nikas, Areti Theodorou, and Epameinondas V Tsianos.
- 1st Division of Internal Medicine, University of Ioannina, Medical School, 45110 Ioannina, Greece.
- J. Hepatol. 2008 Apr 1; 48 (4): 678-80.
AbstractCirrhosis associated with moderate and severe portopulmonary hypertension carries a poor prognosis. Optimal management has not yet been defined. Current treatment options, such as prostacyclin analogues, endothelin antagonists, and phosphodiesterase-5 inhibitors, are characterized by slow onset of action and various adverse effects, particularly in patients with advanced cirrhosis. Here, we report the significant reduction of pulmonary arterial pressure after 1-week terlipressin treatment in a patient with concomitant hepato-renal syndrome. Terlipressin could be a novel and safe treatment for portopulmonary hypertension.
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