• Neuroscience research · Sep 2000

    Involvement of G-protein-activated inwardly rectifying K (GIRK) channels in opioid-induced analgesia.

    • K Ikeda, T Kobayashi, T Kumanishi, H Niki, and R Yano.
    • Laboratory for Neurobiology of Emotion, RIKEN, Brain Science Institute, Wako, Saitama, Japan. ikedak@postman.riken.go.jp
    • Neurosci. Res. 2000 Sep 1; 38 (1): 113-6.

    AbstractTo investigate the role of G-protein-activated inwardly rectifying K+ (GIRK) channels in opioid-induced analgesia, we compared the effects of opioids in wild-type and weaver mutant mice having mutant GIRK channels. In the tail-flick and hot-plate tests, weaver mutant mice displayed significantly lower analgesia after either morphine or (-)-U-50488 administration. These findings suggest that GIRK channel activation is important in the induction of analgesia by opioids.

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